%0 Journal Article
%T Histopathological Assessment and hematotoxicity of Dietary acrylamide on Wistar rats
%A Almoeiz Y Hammad
%A Maha E Osman
%A Warda S Abdelgadir
%J International Journal of Life Sciences
%P 21-25
%D 2013
%I Research Laboratory for Agricultural Biotechnology and Biochemistry (RLABB)
%R 10.3126/ijls.v7i1.8018
%X Acrylamide is a toxic, cancer-causing, industrial chemical used primarily in the preparation of polyacrylamide, which is used principally in water and wastewater treatment and in pulp and paper processing. A significant source of dietary acrylamide is foods cooked at high temperature. Till recently, only known human health effect is neurotoxicity at relatively high doses occurring through occupational exposures. Numerous gaps in knowledge concerning the formation, dietary exposure, and potential for adverse health risks of acrylamide were identified, and the resulting recommendations called for additional research on these topics. Hence the objective of this study was to assess the effects of dietary acrylamide at different doses on tissues and blood of Wistar rats. The results showed no evidence of carcinogenic effect of acrylamide on any of the vital organs, but the main features were growth depression and pathological changes on the liver, kidneys and intestines sufficient to impose significant haematological changes. DOI: http://dx.doi.org/10.3126/ijls.v7i1.8018 International Journal of Life Sciences 7(1): 2013; 21-25
%K Acrylamide
%K histopathological changes
%K hematotoxicity
%U http://www.nepjol.info/index.php/IJLS/article/view/8018