%0 Journal Article
%T Hypocholesterolemic Effect of Ethanol Extract of Ananas comosas (L.) Merr. Leaves in High Cholesterol Fed Albino Rats
%A Mohammed Moinul Islam
%A M Mahabub-Uz-Zaman
%A Rasheda Aktar
%A Nazim Uddin Ahmed
%J International Journal of Life Sciences
%P 57-62
%D 2011
%I Research Laboratory for Agricultural Biotechnology and Biochemistry (RLABB)
%R 10.3126/ijls.v5i1.3739
%X Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 The hypocholesterolemic effect of the ethanol extract of Ananas comosas (Pineapple) was investigated in 5 groups of albino rats, 7 in each group. Group I rat received only distilled water and served as normal control. Groups II, III, IV and   V were made hypercholesterolemic by feeding cholesterol orally suspended in 2% cholic acid mixed soybean oil (1 ml/kg bw) at a dose of 100 mg/kg bw daily up to 60 days. Group II rat received 1 ml distilled water while animals of Group III , IV and V received ethanol extract of Ananas comosas at the dose of 1000 mg/kg, 500 mg/kg and 100 mg/kg body weight respectively daily up to 60 days in addition to cholesterol as above. At the end of 60 th day animals were sacrificed and blood samples were collected for measurement of lipid profiles using enzymatic kit. Administration of cholesterol caused a significant rise (p<0.001) in the serum levels of total cholesterol, LDL-cholesterol and triglycerides. Simultaneous administration of three different doses of Ananas comosas extract namely 1000 mg/kg, 500 mg/kg and 100 mg/kg for 60 days decreased serum cholesterol level by 62%, 47%, and 42% respectively (p<0.001); serum triglycerides level by 62.7%, 58.7%, and 49.09% respectively (p<0.001); serum LDL level by 70.5%, 53.9% and 51.15%, respectively (p<0.01). However, serum HDL level was not affected significantly. The cumulative results clearly indicate ethanol extract of Ananas comosas leaves possesses potent hypocholesterolaemic effect. DOI: http://dx.doi.org/10.3126/ijls.v5i1.3739 International Journal of Life Sciences Vol.5(1) 2011
%K Hypocholesterolemic effect
%K Ananas comosas
%U http://www.nepjol.info/index.php/IJLS/article/view/3739