%0 Journal Article
%T Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)
%A Giuseppina Autore
%A Stefania Marzocco
%A Carmen Formisano
%A Maurizio Bruno
%A Sergio Rosselli
%A Mariem Ben Jemia
%A Felice Senatore
%J Molecules
%P 1571-1578
%D 2015
%I MDPI AG
%R 10.3390/molecules20011571
%X The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.
%K Magydaris tomentosa
%K coumarins
%K furanocoumarins
%K xanthotoxin
%K xanthotoxol
%K isopimpinellin
%K osthole
%K bergaptene
%K MCF-7
%U http://www.mdpi.com/1420-3049/20/1/1571