%0 Journal Article
%T Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine
%A Yasufumi Fuchi
%A Hideto Obayashi
%A Shigeki Sasaki
%J Molecules
%P 1078-1087
%D 2015
%I MDPI AG
%R 10.3390/molecules20011078
%X The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.
%K oxidative damage
%K oxidized nucleoside
%K 8-oxoguanosine
%K 8-nitroguanosine
%K 8-thioguanosine
%U http://www.mdpi.com/1420-3049/20/1/1078