%0 Journal Article
%T Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo
%A Yu-Rong Wang
%A Yuan Xu
%A Zhen-Zhou Jiang
%A Mounia Guerram
%A Bin Wang
%A Xiong Zhu
%A Lu-Yong Zhang
%J Molecules
%P 1661-1675
%D 2015
%I MDPI AG
%R 10.3390/molecules20011661
%X Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis. Animal studies revealed that DPT significantly inhibited tumor growth and decreased microvessel density (MVD) in a xenograft model of gastric cancer. Taken together, our findings provide a framework for further exploration of DPT as a novel chemotherapeutic for human gastric cancer.
%K deoxypodophyllotoxin
%K human gastric cancer
%K cell cycle arrest
%K apoptosis
%K anti-angiogenesis
%U http://www.mdpi.com/1420-3049/20/1/1661