%0 Journal Article
%T Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process
%A Lu¨ªs E. C¨¢rdenas-Galindo
%A Alejandro Islas-J¨¢come
%A Karla M. Colmenero-Mart¨ªnez
%A Antonio Mart¨ªnez-Richa
%A Roc¨ªo G¨¢mez-Montao
%J Molecules
%P 1519-1526
%D 2015
%I MDPI AG
%R 10.3390/molecules20011519
%X A series of five novel bis-1,5-disubstituted-1 H-tetrazoles ( bis-1,5-DS-1 H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%¨C95%) or using mild MW-heating conditions (80%¨C91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds.
%K bis-1
%K 5-disubstituted-1H-tetrazoles
%K Ugi-azide repetitive reaction
%K MW-assisted synthesis
%K catalyst-free
%K chelating agents
%U http://www.mdpi.com/1420-3049/20/1/1519