%0 Journal Article
%T Synthesis and in Silico Evaluation of Novel Compounds for PET-Based Investigations of the Norepinephrine Transporter
%A Catharina Neudorfer
%A Amir Seddik
%A Karem Shanab
%A Andreas Jurik
%A Christina Rami-Mark
%A Wolfgang Holzer
%A Gerhard Ecker
%A Markus Mitterhauser
%A Wolfgang Wadsak
%A Helmut Spreitzer
%J Molecules
%P 1712-1730
%D 2015
%I MDPI AG
%R 10.3390/molecules20011712
%X Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2 H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylamine-based analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.
%K NET
%K ADHD
%K cocaine dependence
%K BAT
%K PET
%K FAPPI
%U http://www.mdpi.com/1420-3049/20/1/1712