%0 Journal Article
%T Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea
%A Germana Esposito
%A Roberta Teta
%A Roberta Miceli
%A Luca S. Ceccarelli
%A Gerardo Della Sala
%A Rosa Camerlingo
%A Elena Irollo
%A Alfonso Mangoni
%A Giuseppe Pirozzi
%A Valeria Costantino
%J Marine Drugs
%P 444-459
%D 2015
%I MDPI AG
%R 10.3390/md13010444
%X The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A ( 3) and B ( 4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
%K Smenospongia aurea
%K marine natural products
%K thiazole
%K structure elucidation
%K anti-tumor lead molecules
%K smenamides
%K solid tumor cell lines
%K apoptosis
%K MTT assays
%U http://www.mdpi.com/1660-3397/13/1/444