%0 Journal Article
%T Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic Fungus Aspergillus sp. 16-5C
%A Ze'en Xiao
%A Shao'e Lin
%A Chunbing Tan
%A Yongjun Lu
%A Lei He
%A Xishan Huang
%A Zhigang She
%J Marine Drugs
%P 366-378
%D 2015
%I MDPI AG
%R 10.3390/md13010366
%X Racemic dinaphthalenone derivatives, (¡À)-asperlone A ( 1) and (¡À)-asperlone B ( 2), and two new azaphilones, 6¡ä-hydroxy-( R)-mitorubrinic acid ( 3) and purpurquinone D ( 4), along with four known compounds, (£¿)-mitorubrinic acid ( 5), (£¿)-mitorubrin ( 6), purpurquinone A ( 7) and orsellinic acid ( 8), were isolated from the cultures of Aspergillus sp. 16-5C. The structures were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR spectra and the structures of 1 further confirmed by single-crystal X-ray diffraction analysis, while the absolute configuration of 3 and 4 were determined by comparing their optical rotation and CD with those of the literature, respectively. Compounds 1, 2 and 6 exhibited potent inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with IC 50 values of 4.24 ¡À 0.41, 4.32 ¡À 0.60 and 3.99 ¡À 0.34 ¦ÌM, respectively.
%K marine fungi
%K Aspergillus sp.
%K asperlones
%K azaphilones
%K MptpB inhibitor
%U http://www.mdpi.com/1660-3397/13/1/366