%0 Journal Article
%T Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents
%A Li-Jun Wang
%A Shuai-Yu Wang
%A Bo Jiang
%A Ning Wu
%A Xiang-Qian Li
%A Bao-Cheng Wang
%A Jiao Luo
%A Meng Yang
%A Shui-Hua Jin
%A Da-Yong Shi
%J Marine Drugs
%P 806-823
%D 2015
%I MDPI AG
%R 10.3390/md13020806
%X A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds ( 4g¨C 4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure¨Cactivity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs.
%K bromophenol
%K indolin-2-one
%K anticancer
%K molecular hybrid
%K structure¨Cactivity relationship
%U http://www.mdpi.com/1660-3397/13/2/806