%0 Journal Article
%T HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
%A Santiago Guerrero
%A Julien Batisse
%A Camille Libre
%A Serena Bernacchi
%A Roland Marquet
%A Jean-Christophe Paillart
%J Viruses
%P 199-218
%D 2015
%I MDPI AG
%R 10.3390/v7010199
%X Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication.
%K HIV-1
%K translation
%K auxiliary proteins
%K IRES
%K leaky-scanning
%K frameshift
%K ribosome shunting
%U http://www.mdpi.com/1999-4915/7/1/199