%0 Journal Article
%T Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454
%A Seyed Mohammad Jazaeri Farsani
%A Bas B. Oude Munnink
%A Marta Canuti
%A Martin Deijs
%A Matthew Cotten
%A Maarten F. Jebbink
%A Joost Verhoeven
%A Paul Kellam
%A Katherine Loens
%A Herman Goossens
%A Margareta Ieven
%A Lia van der Hoek
%J Viruses
%P 239-251
%D 2015
%I MDPI AG
%R 10.3390/v7010239
%X Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.
%K rhinovirus C54
%K virus discovery
%K antibody capture VIDISCA-454
%U http://www.mdpi.com/1999-4915/7/1/239