%0 Journal Article
%T Retracted HIV Study Provides New  Information about the Status of the <i>in</i> <i>Vitro</i> Inhibition of DNA Replication by Backbone Methylation
%A Henk M. Buck
%J Journal of Biophysical Chemistry
%P 29-34
%@ 2153-0378
%D 2015
%I Scientific Research Publishing
%R 10.4236/jbpc.2015.61003
%X In this publication attention is given to a retracted article in <em>Science</em> at the end of 1990 concerning the HIV-1 inhibition by a modified backbone DNA as the phosphatemethylated DNA. A disproportion in the presented data resulted in a faulty generalization of the (bio)chemical characteristics of the phosphatemethylated DNA (18- and 20-nucleotides). In the confusion and the outside pressure a related study in Nucleic Acids Research on the<em> in vitro</em> dynamics of a regiospecific inhibition of DNA duplication with long (20- and 18-nucleotides) and short (8-nucleotides) phosphatemethylated DNA was completely ignored. A restoration will be given based on a comprehensive view demonstrating the unique molecular and conformational properties of phosphatemethylated DNA in their (bio)chemistry towards natural DNA and RNA (HIV-1 RNA loops).
%K Phosphatemethylated DNA
%K Conformational Study
%K HIV-1
%K &lt
%K i&gt
%K E. coli pab B&lt
%K /i&gt
%K Gene
%K &lt
%K i&gt
%K in&lt
%K /i&gt
%K &lt
%K i&gt
%K Vitro&lt
%K /i&gt
%K Inhibition of DNA Replication
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53583