%0 Journal Article
%T Screening Donated Blood for Transfusion Transmitted Infections by Serology along with NAT and Response Rate to Notification of Reactive Results: An Indian Experience
%A Rahul Chaurasia
%A Shamsuz Zaman
%A Bankim Das
%A Kabita Chatterjee
%J Journal of Blood Transfusion
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/412105
%X Background. Transfusion safety begins with healthy donors. A fundamental part of preventing transfusion transmitted infections (TTIs) is to notify and counsel reactive donors. Donor notification and counselling protect the health of the donor and prevent secondary transmission of infectious diseases. Methods. 113,014 donations were screened for TTIs, namely, HIV, HBV, HCV, and syphilis, by serology and nucleic acid testing. All reactive donors were retested (wherever possible) and notified of their status by telephone or letter. All initial reactive screens were followed over six months. Results. We evaluated 2,838 (2.51%) cases with reactive screening test results (1.38% HBV, 0.54% HCV, 0.27% HIV, and 0.32% syphilis). Only 23.3% of donors (662) responded to notification. The response among voluntary donors was better as compared to the replacement donors (43.6% versus 21.2%). Only 373 (56.3%) responsive donors followed their first attendance at referral specialties. Over six months, only 176 of 662 (26.6%) reactive donors received treatment. Conclusion. Our study shed light on the importance of proper donor counselling and notification of TTI status to all reactive donors who opt to receive this information. There is also an urgent need to formulate the nationally acceptable guidelines for notification and follow-up of reactive donors. 1. Introduction Blood transfusion is safer than ever before through continuous improvements in donor recruitment, screening, testing of donated blood with increasingly sensitive assays, and appropriate clinical use of blood [1]. Serologic testing for transfusion transmitted diseases had historically been the foundation of blood screening, while newer strategies like nucleic acid testing (NAT) have helped further shorten the ˇ°window periodˇ± [2]. Currently, no technology exists to completely detect all window period donations. No matter how sensitive NAT becomes, we will never be able to completely close the exposure-to-seroconversion window period. The general public and media might believe that with the advancement in testing technologies zero risk blood products are currently available. This generalization is far from reality as judged by our current experience with new testing methodologies. Breakthrough transmissions of viruses (HIV-1 and HCV) had occurred as late as 2009 due to NAT failures because of low level of viraemia and/or suboptimal amplification efficiency [3]. Moreover, threat of infectious agents entering the blood supply is not static and may evolve as new pathogens emerge or as old ones change their
%U http://www.hindawi.com/journals/jbt/2014/412105/