%0 Journal Article
%T Benzoylacetone as a Building Block in Heterocyclic Synthesis: Synthesis of Polyfunctionally Substituted Pyridinethione and Its Derivatives
%A Abdel Haleem Mostafa Hussein
%A Fathi Ali Abu-Shanab
%A Sayed Abdel Hamed Sayed Mousa
%J Open Access Library Journal
%V 2
%N 1
%P 1-9
%@ 2333-9721
%D 2015
%I Open Access Library
%R 10.4236/oalib.1101274
%X The Hantzsch amide derivatives 1 are prepared by reaction of a mixture of
two moles of benzoylacetone, aqueous ammonia and aromatic aldehydes. Also, the
reaction of benzoylacetone with a mixture of urea or thiourea and aromatic
aldehydes afforded pyrimidine derivatives 2a-h. Pyridinethione derivative 3 was
reacted with <i>¦Á</i>¨Chaloketones and <i>¦Á</i>¨Chalonitriles 4a-e
to afford the S-alky- lated derivatives 5a-e which cyclized into 6b-e and 7.
Reactions of compound 7 with glacial acetic acid/acetic anhydride gave 8 which
led to 9a and 9b on treatment with ammonium acetate/acetic acid and aniline.
Also, treatment of 7 with formamide, hydrazine hydrate and benzoyl
isothiocyanate afforded 10, 11 and 13. Reactions of 3 with arylidenemalononitrile
14 in ethanolic triethylamine yielded 1:1 addact 17a-c.
%K Pyridines
%K Pyrimidines
%K Pyridinthione
%K Pyridothienopyrimidine and Isoquinolines
%U http://www.oalib.com/paper/3134366