%0 Journal Article
%T The First Synthesis of Sessiline
%A Viktor Ilkei
%A Korn¨¦l Farag¨®
%A Zsuzsanna S¨˘nta
%A Mikl¨®s D¨¦k¨˘ny
%A L¨˘szl¨® Hazai
%A Csaba Sz¨˘ntay Jr.
%A Csaba Sz¨˘ntay
%A Gy&ouml
%A rgy Kalaus
%J International Journal of Organic Chemistry
%P 309-313
%@ 2161-4695
%D 2014
%I Scientific Research Publishing
%R 10.4236/ijoc.2014.45033
%X Sessiline
is an alkaloid which is recently isolated from the fruits of <i>Acanthopanax sessiliflorus</i>. The molecule
contains two five-membered heterocyclic units joined together by an acylaminocarbinol-ether
type bond. Here, we describe the first, simple synthesis of sessiline from 5-hydroxypyrrolidin-2-one and 5-hydroxymethylfurfural, which are prepared from succinimide
and furfuryl alcohol, respectively. The coupling reaction takes place on moderate
heating under neat conditions.
%K Sessiline
%K Acylaminocarbinol
%K Iminium Ion
%K Alkaloid Synthesis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52662