%0 Journal Article
%T Simple Reduction of Hydantoins with Sodium Borohydride
%A Jun-Ichi Yamaguchi
%A Emiko Shibuta
%A Yoshie Oishi
%J International Journal of Organic Chemistry
%P 286-291
%@ 2161-4695
%D 2014
%I Scientific Research Publishing
%R 10.4236/ijoc.2014.45031
%X The reduction of various hydantoins with sodium borohydride gave the corresponding 4-hydroxy- 2-imidazolidinones in high yields. In contrast, reduction employing a boron trifluoride etherate-sodium borohydride system generated 2-imidazolidinones. In both reductions, the reactivity of the hydantoin was dependent on its substituents. The Lewis acid-promoted reactions of a 4-hydroxy-2-imidazolidinone with nucleophiles were also investigated.
%K Hydantoin
%K Reduction
%K Imidazolidinone
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52659