%0 Journal Article
%T Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study
%A M. Mushfiqur Rahman
%A Jolanda Cibere
%A Aslam H. Anis
%A Charlie H. Goldsmith
%A Jacek A. Kopec
%J International Journal of Rheumatology
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/620920
%X Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician＊s visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors. Results. At baseline, the mean age of OA cases was 61 years and 60.5% were women. Over 12 years of mean follow-up, the incidence rate (95% CI) of diabetes was 11.2 (10.90每11.50) per 1000 person years. Adjusted RRs (95% CI) for diabetes were 1.27 (1.15每1.41), 1.21 (1.08每1.35), 1.16 (1.04每1.28), and 0.99 (0.86每1.14) for younger women (age 20每64 years), older women (age ≡ 65 years), younger men, and older men, respectively. Conclusion. Younger adults and older women with OA have increased risks of developing diabetes compared to their age-sex matched non-OA counterparts. Further studies are needed to confirm these results and to elucidate the potential mechanisms. 1. Introduction Diabetes mellitus is a common chronic health condition worldwide. It is predicted that the global prevalence of this disease among adults will rise from 6.4% in 2010 to 7.7% by 2030 [1]. Diabetes affects an estimated 8.3% of Americans and 8.8% of Canadians [2, 3], resulting in severe damage to the cardiovascular system, kidneys, eyes, and other organs. Metabolic syndrome is a group of conditions such as hypertension, hyperlipidemia, obesity, and elevated blood glucose that are linked with diabetes [4]. Other common risk factors for diabetes include age, sex, family history, ethnicity, socioeconomic status (SES), heart disease, history of gestational diabetes, physical inactivity, alcohol consumption, and diet [5, 6]. As the prevalence of diabetes has risen, it has been imperative to identify determinants beyond these traditional risk factors. Studies have shown that the increased risk of diabetes is caused in part by physical inactivity and that physically active individuals have lower rates of the disease [6, 7]. In addition, muscle strength was found to be significantly lower among adults with type 2 diabetes [8]. Osteoarthritis (OA) is the most common type of rheumatic disease and a leading cause of disability [9每11].
%U http://www.hindawi.com/journals/ijr/2014/620920/