%0 Journal Article
%T <sup>11</sup>C-Labeling of the C(1)-C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer
%A Chunguang Han
%A Hisashi Doi
%A Junji Kimura
%A Yoichi Nakao
%A Masaaki Suzuki
%J International Journal of Organic Chemistry
%P 269-277
%@ 2161-4695
%D 2014
%I Scientific Research Publishing
%R 10.4236/ijoc.2014.44029
%X <sup>11</sup>C-labeled C1-C10 partial structure of kulokekahilide-2 (1) was successfully synthesized based on Pd<sup>0</sup>-mediated rapid <i>C</i>-[<sup>11</sup>C]methylation using [<sup>11</sup>C]methyl iodide and pinacol alkenylboronate. The preparation of organoboron intermediate via olefin cross-metathesis is also a crucial procedure for the synthesis of <sup>11</sup>C-labeling C1-C10 dihy-droxy acid moiety of 1.<br />
%K Kulokekahilide-2
%K Carbon-11
%K Boron
%K C-C Coupling
%K Isotopic Labeling
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52525