%0 Journal Article
%T Expression Imbalance of Cholinergic M<sub>2</sub> and M<sub>3</sub> Receptors Contributes to the Motility Reduction of the Small Intestine in Spleen Qi Deficiency
%A Fan Zhao
%A Xudong Liu
%A Wenjun Liu
%A Jiyan Cai
%A Lingzhi Wang
%A Huaxin Yu
%A Lu Wang
%A Lide Zhang
%A Deshan Wang
%A Dehong Shan
%J Chinese Medicine
%P 165-169
%@ 2151-1926
%D 2014
%I Scientific Research Publishing
%R 10.4236/cm.2014.54020
%X Objective: To study roles of cholinergic M<sub>2</sub> and M<sub>3</sub> receptors in the motility reduction of small intestine (SI) in spleen qi deficiency. Methods: 16 male SD rats were randomly divided in the control group and spleen qi deficiency group (model group)¡ª8 rats each group; spleen qi deficiency model of the improper diet and overfatigue was established; the SI propelling rate (SIPR) was used to evaluate the SI motility; ELISA was used to measure concentrations of acetylcholine (ACh), cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) in the SI tissue; immohistochemistry was employed to detect expressions of cholinergic M<sub>2</sub> and M<sub>3</sub> receptors. Results: Compared with those in the control group, SIPR was reduced; expression of M<sub>2</sub> receptors was increased; and expression of M<sub>3</sub> receptors and concentrations of cAMP and PKA were decreased, significantly, in the model group. Conclusions: Expression imbalance of cholinergic M<sub>2</sub> and M<sub>3</sub> receptors might contribute to the motility reduction of the SI in spleen qi deficiency.
%K Spleen Qi Deficiency
%K Small Intestine Motility
%K M&lt
%K sub&gt
%K 2&lt
%K /sub&gt
%K Receptor
%K M&lt
%K sub&gt
%K 3&lt
%K /sub&gt
%K Receptor
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52206