%0 Journal Article
%T An Intentional Poisoning by Lormetazepam in a Patient Treated with Nordiazepam
%A Phak-Rop Pos Pok
%A Emilie Berland
%A Michel Mauras
%A Magali Val¨¨s
%A Erika Kuhlmann
%J Forensic Medicine and Anatomy Research
%P 107-112
%@ 2327-4107
%D 2014
%I Scientific Research Publishing
%R 10.4236/fmar.2014.24018
%X A case of suspected poisoning by benzodiazepines is presented in this paper. Toxicological analyses were applied on the blood collected 48 hours after the facts. GC-MS and HPLC-DAD have detected only nordiazepam which was prescribed in the treatment. Therefore, LC-MS/MS has detected lormetazepam and lorazepam (major metabolite of lormetazepam) in addition of nordiazepam. The concentrations of lormetazepam, lorazepam and nordiazepam measured in blood were 6.8, 6.3, and 16.2 ng/mL, respectively. The initial concentration of each drug at the relevant time, has been calculated from these residual concentrations, using an extrapolation approach. According to estimates, only lormetazepam (189 ng/mL) and lorazepam (68 ng/mL), were active at the target moment. A poisoning by lormetazepam was then considered. The more technology we have, the greater chance we have to get an outcome that is favorable to justice.
%K Benzodiazepines
%K Discrimination between Poison and Medication
%K LC-MS/MS
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51061