%0 Journal Article
%T Hemoglobin S Polymerization Effect on Water Self-Diffusion Coefficient
%A Manuel A. Lores Guevara
%A Juan C. Garc¨Şa-Naranjo
%A Yulianela Mengana
%A Jorge Pereira
%J Advances in Biological Chemistry
%P 388-394
%@ 2162-2191
%D 2014
%I Scientific Research Publishing
%R 10.4236/abc.2014.46044
%X The transversal relaxation time, the effective transversal relaxation time and the water self-diffusion coefficient are evaluated during hemoglobin S polymerization. One homogeneous permanent magnet and one inhomogeneous and portable unilateral magnet with a very strong and constant static magnetic field gradient were utilized. The Carr-Purcell-Meiboom-Gill method was used before and after placing the studied samples 24 hours at 36°C to guarantee the polymerization. The transversal relaxation shows two exponents after polymerization supporting the concept of partially polymerized hemoglobin. The effective transversal relaxation time decreases around 40%, which can be explained by the increase of water self-diffusion coefficient 1.8 times as a main value. This result can be explained considering the effects of the agglutination process on the obstruction and hydration effects in a partially polymerized solution.
%K Sickle Cell Disease
%K Water Self-Diffusion Coefficient
%K T&lt
%K sub&gt
%K 2&lt
%K /sub&gt
%K NMR
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50363