%0 Journal Article
%T 通路分析提示钙信号转导通路与酒精依赖关联<br>Pathway Analysis Suggest the Calcium Signaling Pathway 
Associated with Alcohol Dependence
%A 郭艳芳
%J Hans Journal of Biomedicine
%P 1-6
%@ 2161-8984
%D 2014
%I Hans Publishing
%R 10.12677/HJBM.2014.41001
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:12px;line-height:1.5;\">背景：</span><span style=\"font-size:12px;line-height:1.5;\">酒精依赖是一种严重而常见的复杂疾病，大量关联研究常致力寻找其易感基因，目前对已发现的遗传变异还缺乏整体的分析和认识。</span><span style=\"font-size:12px;line-height:1.5;\">方法：</span><span style=\"font-size:12px;line-height:1.5;\">采用基因富集通路分析法对来自</span><span style=\"font-size:12px;line-height:1.5;\">31</span><span style=\"font-size:12px;line-height:1.5;\">项饮酒相关研究的</span><span style=\"font-size:12px;line-height:1.5;\">1438</span><span style=\"font-size:12px;line-height:1.5;\">个单核苷酸多态性进行分析。</span><span style=\"font-size:12px;line-height:1.5;\">结果：</span><span style=\"font-size:12px;line-height:1.5;\">钙信号传导通路</span><span style=\"font-size:12px;line-height:1.5;\">(</span><span style=\"font-size:12px;line-height:1.5;\">hsa0</span><span style=\"font-size:12px;line-height:1.5;\">4020) (P = 5.4 </span><span style=\"font-size:12px;line-height:1.5;\">′</span><span style=\"font-size:12px;line-height:1.5;\"> 10</span><span style=\"font-size:12px;line-height:1.5;\">？</span><span style=\"font-size:12px;line-height:1.5;\">5</span><span style=\"font-size:12px;line-height:1.5;\">)</span><span style=\"font-size:12px;line-height:1.5;\">显示出最显著的关联富集，经多重检验校正后仍显著</span><span style=\"font-size:12px;line-height:1.5;\">(</span><span style=\"font-size:12px;line-height:1.5;\">bonferroni P = 0.8 </span><span style=\"font-size:12px;line-height:1.5;\">′</span><span style=\"font-size:12px;line-height:1.5;\"> 10</span><span style=\"font-size:12px;line-height:1.5;\">？</span><span style=\"font-size:12px;line-height:1.5;\">3</span><span style=\"font-size:12px;line-height:1.5;\">, </span><span style=\"font-size:12px;line-height:1.5;\">FDR = 0.6 </span><span style=\"font-size:12px;line-height:1.5;\">′</span><span style=\"font-size:12px;line-height:1.5;\"> 10</span><span style=\"font-size:12px;line-height:1.5;\">？</span><span style=\"font-size:12px;line-height:1.5;\">2</span><span style=\"font-size:12px;line-height:1.5;\">)</span><span style=\"font-size:12px;line-height:1.5;\">。有研究证实钙信号转导通路在脑功能调节中必不可少，该通路中的基因与酒精对身体的抑郁作用有关。</span><span style=\"font-size:12px;line-height:1.5;\">结论：</span><span style=\"font-size:12px;line-height:1.5;\">钙信号转导通路可能对酒精依赖具有重要影响。<span style=\"text-align:justify;white-space:normal;\">&lt;br/&gt;</span></span><span style=\"font-size:12px;line-height:1.5;\">Background:</span><span style=\"font-size:12px;line-height:1.5;\"> Alcohol dependence (AD) is a serious and
common public health problem. A large number of association studies were
conducted to identify susceptibility genes of AD, but
%K 全基因组关联研究；通路分析；酒精依赖<br>Genome-Wide Association Study
%K Pathway Analysis
%K Alcohol Dependence
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=13072