%0 Journal Article
%T 持续泵入咪达唑仑及积极医护干预治疗小儿癫痫持续状态疗效研究<br>
The Curative Effect Research about Continuous Intravenous Drip of Midazolam and Positive Health Care Intervention Treating Children with Status Epilepticus
%A 田勇
%J Advances in Clinical Medicine
%P 21-24
%@ 2161-8720
%D 2013
%I Hans Publishing
%R 10.12677/ACM.2013.33006
%X <p>
	<b><span style=\"font-family:宋体;font-size:10pt;\">目的：</span></b><span style=\"font-family:宋体;font-size:10pt;\">研究咪达唑仑持续</span><span style=\"font-family:宋体;font-size:10pt;\">静脉泵入治疗小儿癫痫持续状态的临床疗效，同时探讨积极的医护干预对于控制感染、意识障碍及呼吸抑制等不良反应的疗效。<b>方法</b></span><b><span style=\"font-family:宋体;font-size:10pt;\">：</span></b><span style=\"font-family:宋体;font-size:10pt;\">选取</span><span style=\"font-size:10pt;\">2011</span><span style=\"font-family:宋体;font-size:10pt;\">年</span><span style=\"font-size:10pt;\">12</span><span style=\"font-family:宋体;font-size:10pt;\">月</span><span style=\"font-size:10pt;\">~2012</span><span style=\"font-family:宋体;font-size:10pt;\">年</span><span style=\"font-size:10pt;\">10</span><span style=\"font-family:宋体;font-size:10pt;\">月收入院的癫痫持续状态</span><span style=\"font-size:10pt;\">(SE)</span><span style=\"font-family:宋体;font-size:10pt;\">患儿</span><span style=\"font-size:10pt;\">90</span><span style=\"font-family:宋体;font-size:10pt;\">例为观察对象，随机分为两组：治疗组</span><span style=\"font-size:10pt;\">46</span><span style=\"font-family:宋体;font-size:10pt;\">例，给予咪达唑仑持续静脉泵入，并将</span><span style=\"font-size:10pt;\">46</span><span style=\"font-family:宋体;font-size:10pt;\">例患儿随机分为两组，每组均为</span><span style=\"font-size:10pt;\">23</span><span style=\"font-family:宋体;font-size:10pt;\">例患儿，一组给予积极医护干预，另一组给予常规的医疗护理；对照组</span><span style=\"font-size:10pt;\">44</span><span style=\"font-family:宋体;font-size:10pt;\">例，仅应用传统的一线抗癫痫药物</span><span style=\"font-size:10pt;\">(AEDs)</span><span style=\"font-family:宋体;font-size:10pt;\">治疗，同样将</span><span style=\"font-size:10pt;\">44</span><span style=\"font-family:宋体;font-size:10pt;\">例患儿随机分为两组，每组均为</span><span style=\"font-size:10pt;\">22</span><span style=\"font-family:宋体;font-size:10pt;\">例患儿，一组给予积极医护干预，另一组给予常规的医疗护理，最后将两组疗效进行对照研究，并比较两种不同医护干预产生不良反应的发生概率，组间比较，最后行统计学处理。<b>结果</b></span><b><span style=\"font-family:宋体;font-size:10pt;\">：</span></b><span style=\"font-family:宋体;font-size:10pt;\">治疗组治疗有效率明显高于对照组</span><span style=\"font-size:10pt;\">(P &lt; 0.05)</span><span style=\"font-family:宋体;font-size:10pt;\">，治疗组的咪达唑仑安全有效剂量为</span><span style=\"font-size:10pt;\">0.1~0.5 mg/</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">kg·h</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">，积极医护干预组不良反应发生率</span><span style=\"font-size:10pt;\">(</span><span style=\"font-size:10pt;\">15.2%</span><span style=\"font-size:10pt;\">)</span><span style=\"font-family:宋体;font-size:10pt;\">明显低于对照组患儿</span><span style=\"font-size:10pt;\">(P &lt; 0.05)</span><span
%K 咪达唑仑；癫痫持续状态；药物疗法<br>
Midazolam
%K Status Epilepticus
%K Drug Therapy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=12386