%0 Journal Article
%T Bilateral Mixed Germ Cell Tumour in an Adolescent Girl with Premature Ovarian Failure
%A Priyankur Roy
%A Bivas Biswas
%A Suman Paul
%A Lisa Choudhrie
%A Ruby Jose
%J Open Journal of Obstetrics and Gynecology
%P 805-808
%@ 2160-8806
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojog.2014.413111
%X Germ cell tumours (GCTs)
of the ovary are rare, comprising approximately 20% of all ovarian tumors with
the malignant variant accounting for less than 5% of all ovarian neoplasms.
Malignant mixed germ cell tumours are rarer still with dysgerminoma & yolk
sac tumour being the most common components with three component variants being
categorised in the rarest of rare varieties. Bilateral dysgerminomas occur in
15% of germ cell neoplasms but rarely present with premature ovarian failure.
We present the case of an adolescent girl with a short history of abdominal
pain and distension with amenorrhoea for a year. Clinical and radio ogical
examination revealed a pelvic/adnexal mass with elevation of tumour markers and
she had to undergo a staging laparotomy with bilateral salpingo-oophorectomy.
Histopatholgy examination was reported as malignant mixed germ cell tumour of
left ovary, predominantly with immature teratoma and minor components of
yolk-sac tumour and dysgerminoma and right ovary with dysgerminoma. In view of
mixed germ cell disease, she was planned for adjuvant chemotherapy.
%K Mixed Germ Cell Tumour
%K Teratoma
%K Dysgerminoma
%K Yolk Sac Tumour
%K Premature Ovarian Failure
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50029