%0 Journal Article
%T A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
%A Jianyong Yuan
%A Kai Liu
%A Lun Li
%A Yong Yuan
%A Xuelei Liu
%A Yanwu Li
%J Molecules
%P 14999-15004
%D 2014
%I MDPI AG
%R 10.3390/molecules190914999
%X A facile synthetic route of rivaroxaban has been developed. Using commercially available ( R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
%K rivaroxaban
%K oxazolidinone
%K Goldberg coupling reaction
%U http://www.mdpi.com/1420-3049/19/9/14999