%0 Journal Article
%T Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
%A Mehlika Dilek Alt£¿ntop
%A Ahmet £¿zdemir
%A G¨¹lhan Turan-Zitouni
%A Sinem Ilg£¿n
%A £¿zlem Atl£¿
%A Fatih Demirci
%A Zafer As£¿m Kaplanc£¿kl£¿
%J Molecules
%P 14809-14820
%D 2014
%I MDPI AG
%R 10.3390/molecules190914809
%X Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl)furan-2-yl)methylene)hydrazinyl]-4-(4-fluorophenyl)thiazole and 2-[2-((5-(4-chloro-2-nitrophenyl)furan-2-yl)methylene) hydrazinyl]-4-(4-methoxyphenyl)thiazole were found to be the most effective antifungal compounds against Candida utilis, with a MIC value of 250 ¦Ìg/mL, when compared with fluconazole (MIC = 2 ¦Ìg/mL). Additionally, the synthesized compounds were evaluated for their in vitro cytotoxic effects on the MCF-7 and NIH/3T3 cell lines. As a result, 2-[2-((5-(4-chloro-2-nitrophenyl)furan-2-yl)methylene)hydrazinyl]-4-(4-chlorophenyl)thiazole was identified as the most promising anticancer compound against MCF-7 cancer cells due to its inhibitory effects (IC 50 = 125 ¦Ìg/mL) and relatively low toxicity towards the NIH/3T3 cell line (IC 50 > 500 ¦Ìg/mL).
%K thiazole
%K hydrazone
%K furan
%K anticancer activity
%K anticandidal activity
%U http://www.mdpi.com/1420-3049/19/9/14809