%0 Journal Article
%T Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse
%A Divya Vohora
%A Malay Bhowmik
%J Frontiers in Systems Neuroscience
%D 2012
%I Frontiers Media
%R 10.3389/fnsys.2012.00072
%X Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/neurochemical evidences available so far following H3R antagonists in the pathophysiology of Alzheimer's disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia, and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3R inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
%K histamine H3 receptor
%K Alzheimer's disease
%K ADHD
%K schizophrenia
%K drug abuse
%U http://www.frontiersin.org/Journal/10.3389/fnsys.2012.00072/abstract