%0 Journal Article
%T Do Manual and Voxel-Based Morphometry Measure the Same? A Proof of Concept Study
%A Niels K. Focke
%A Sarah Trost
%A Walter Paulus
%A Peter Falkai
%A Oliver Gruber
%J Frontiers in Psychiatry
%D 2014
%I Frontiers Media
%R 10.3389/fpsyt.2014.00039
%X Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on a whole brain basis. However, it is often criticized for potential confounds, mainly based on imperfect spatial registration. We therefore aimed to evaluate if VBM and ˇ°gold standardˇ± manual volumetry are measuring the same effects with respect to subcortical gray matter volumes. Manual regions-of-interest were drawn in the hippocampus, amygdala, nucleus accumbens, thalamus, putamen, pallidum, and caudate nucleus bilaterally. Resulting volumes were used for a whole brain VBM correlation analysis with Statistical Parametric Mapping (SPM8). The hippocampus, amygdala, putamen, and caudate nucleus were correctly identified by SPM using the contemporary high-dimensional normalization (DARTEL toolbox). This strongly suggests that VBM and manual volumetry both are indeed measuring the same effects with regard to subcortical brain structures.
%K voxel-based morphometry
%K manual volumetry
%K validation
%K DARTEL
%K mixed psychiatric sample
%U http://www.frontiersin.org/Journal/10.3389/fpsyt.2014.00039/abstract