%0 Journal Article
%T bZIPs and WRKYs: two large transcription factor families executing two different functional strategies
%A Carles M. Llorca
%A Maren Potschin
%A Ulrike Zentgraf
%J Frontiers in Plant Science
%D 2014
%I Frontiers Media
%R 10.3389/fpls.2014.00169
%X bZIPs and WRKYs are two important plant transcription factor (TF) families regulating diverse developmental and stress-related processes. Since a partial overlap in these biological processes is obvious, it can be speculated that they fulfill non-redundant functions in a complex regulatory network. Here, we focus on the regulatory mechanisms that are so far described for bZIPs and WRKYs. bZIP factors need to heterodimerize for DNA-binding and regulation of transcription, and based on a bioinformatics approach, bZIPs can build up more than the double of protein interactions than WRKYs. In contrast, an enrichment of the WRKY DNA-binding motifs can be found in WRKY promoters, a phenomenon which is not observed for the bZIP family. Thus, the two TF families follow two different functional strategies in which WRKYs regulate each other¡¯s transcription in a transcriptional network whereas bZIP action relies on intensive heterodimerization.
%K bZIPs
%K WRKYs
%K DNA-binding
%K heterodimerization
%K regulatory mechanisms
%K G/C box accumulation
%K W-box accumulation
%U http://www.frontiersin.org/Journal/10.3389/fpls.2014.00169/abstract