%0 Journal Article
%T Inflammatory Injury to the Neonatal Brain ¨C What Can We Do?
%A Noa Ofek-Shlomai
%A Itai Berger
%J Frontiers in Pediatrics
%D 2014
%I Frontiers Media
%R 10.3389/fped.2014.00030
%X Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic¨Cischemic, inflammatory, or both. This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. Current options of anti-inflammatory measures for neonates remain quite limited. We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1 receptor antagonists, erythropoietin, caffeine, estradiol, insulin-like growth factor, and melatonin as well as endogenous protectors, and genetic regulation of inflammation. If successful, these may decrease mortality and long-term morbidity among term and pre-term infants.
%K inflammation
%K neonatal
%K brain injury
%K neuro-developmental outcome
%K treatment
%U http://www.frontiersin.org/Journal/10.3389/fped.2014.00030/abstract