%0 Journal Article
%T FEASIBILITY OF IMAGE-GUIDED RADIOTHERAPY FOR CARDIAC SPARING IN PATIENTS WITH LEFT-SIDED BREAST CANCER
%A Claire LEMANSKI
%A Juliettte Thariat
%A Satya Bose
%A Jacqueline Vock
%A Rick Davis
%A Alexander Chi
%A Juan Godinez
%A ULF L. Karlsson
%A Nam P. Nguyen
%A Vincent Vinh-Hung
%J Frontiers in Oncology
%D 2014
%I Frontiers Media
%R 10.3389/fonc.2014.00257
%X Patients with left-sided breast cancer are at risk of cardiac toxicity because of cardiac irradiation during radiotherapy with the conventional 3-dimensional conformal technique (3D-CRT). In addition, many patients may receive chemotherapy prior to radiation which may damage the myocardium and may increase the potential for late cardiac complications. New radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) may decrease the risk of cardiac toxicity because of the steep dose gradient limiting the volume of the heart irradiated to a high dose. Image-guided radiotherapy (IGRT) is a new technique of IMRT delivery with daily imaging which may further reduce excessive cardiac irradiation. Preliminary results of IGRT for cardiac sparing in patients with left-sided breast cancer are promising and need to be investigated in future prospective clinical studies.
%K breast cancer
%K cardiac toxicity
%K left breast
%K IGRT
%K prevention
%U http://www.frontiersin.org/Journal/10.3389/fonc.2014.00257/abstract