%0 Journal Article
%T Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes
%A Zemin Zhou
%A Peter E. Jensen
%J Frontiers in Immunology
%D 2013
%I Frontiers Media
%R 10.3389/fimmu.2013.00262
%X Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.
%K type-1 diabetes
%K HLA-DQ
%K HLA-DM
%K invariant chain
%K autoreactive T cells
%K negative selection
%U http://www.frontiersin.org/Journal/10.3389/fimmu.2013.00262/abstract