%0 Journal Article
%T Which Antibody Functions are Important for an HIV Vaccine?
%A Bin Su
%A Christiane Moog
%J Frontiers in Immunology
%D 2014
%I Frontiers Media
%R 10.3389/fimmu.2014.00289
%X HIV antibody (Ab) functions capable of preventing mucosal cell-free or cell-to-cell HIV transmission are critical for the development of effective prophylactic and therapeutic vaccines. In addition to CD4+ T cells, other potential HIV-target cell types including antigen-presenting cells (APCs) (dendritic cells, macrophages) residing at mucosal sites are infected. Moreover, the interactions between APCs and HIV lead to HIV cell-to-cell transmission. Recently discovered broadly neutralizing antibodies (NAbs) are able to neutralize a broad spectrum of HIV strains, inhibit cell-to-cell transfer, and efficiently protect from infection in the experimentally challenged macaque model. However, the 31% protection observed in the RV144 vaccine trial in the absence of detectable NAbs in blood samples pointed to the possible role of additional Ab inhibitory functions. Increasing evidence suggests that IgG Fc¦Ã receptor (Fc¦ÃR)-mediated inhibition of Abs present at the mucosal site may play a role in protection against HIV mucosal transmission. Moreover, mucosal IgA Abs may be determinant in protection against HIV sexual transmission. Therefore, defining Ab inhibitory functions that could lead to protection is critical for further HIV vaccine design. Here, we review different inhibitory properties of HIV-specific Abs and discuss their potential role in protection against HIV sexual transmission.
%K HIV
%K mucosal HIV vaccine
%K cell-to-cell transfer
%K neutralizing antibodies
%K non-neutralizing inhibitory antibodies
%K Fc¦ÃR
%K antigen-presenting cells
%K ADCC
%U http://www.frontiersin.org/Journal/10.3389/fimmu.2014.00289/abstract