%0 Journal Article
%T Regulation of the NF-百B-Mediated Transcription of Inflammatory Genes
%A Dev Bhatt
%A Sankar Ghosh
%J Frontiers in Immunology
%D 2014
%I Frontiers Media
%R 10.3389/fimmu.2014.00071
%X The NF-百B family of transcription factors plays a central role in the inducible expression of inflammatory genes during the immune response, and the proper regulation of these genes is a critical factor in the maintenance of immune homeostasis. The chromatin environment at stimulus-responsive NF-百B sites is a major determinant in transcription factor binding, and dynamic alteration of the chromatin state to facilitate transcription factor binding is a key regulatory mechanism. NF-百B is in turn able to influence the chromatin state through a variety of mechanisms, including the recruitment of chromatin modifying co-activator complexes such as p300, the competitive eviction of negative chromatin modifications, and the recruitment of components of the general transcriptional machinery. Frequently, the selective interaction with these co-activators is dependent on specific post-translational modification of NF-百B subunits. Finally, the mechanisms of inducible NF-百B activity in different immune cell types seem to be largely conserved. The diversity of cell-specific NF-百B-mediated transcriptional programs is established at the chromatin level during cell differentiation by lineage-defining transcription factors. These factors generate and maintain a cell-specific chromatin landscape that is accessible to NF-百B, thus restricting the inducible transcriptional response to a cell-appropriate output.
%K transcription
%K chromatin
%K gene expression
%K NF-kappaB
%K signaling
%K transcription factor
%U http://www.frontiersin.org/Journal/10.3389/fimmu.2014.00071/abstract