%0 Journal Article
%T Reduced Glycemic Variability in Diazoxide-Responsive Children with Congenital Hyperinsulinism Using Supplemental Omega-3-Polyunsaturated Fatty Acids; A Pilot Trial with MaxEPAR
%A Mars Skae
%A Hima Bindu Avatapalle
%A Indraneel Banerjee
%A Lindsey Rigby
%A Peter Foster
%A Christiana Charalambous
%A Louise Bowden
%A Raja Padidela
%A Leena Patel
%A Sarah Ehtisham
%A Karen E. Cosgrove
%A Mark J. Dunne
%A Peter E. Clayton
%J Frontiers in Endocrinology
%D 2014
%I Frontiers Media
%R 10.3389/fendo.2014.00031
%X Objective: Congenital hyperinsulinism (CHI) is a rare condition of hypoglycemia where therapeutic options are limited and often complicated by side-effects. Omega-3-polyunsaturated fatty acids (PUFA), which can suppress cardiac myocyte electrical activity, may also reduce ion channel activity in insulin-secreting cells. PUFA supplements in combination with standard medical treatment may improve glucose profile and may reduce glycemic variability in diazoxide-responsive CHI.
%K congenital hyperinsulinism
%K hypoglycemia
%K clinical trial
%K omega-3-polyunsaturated fatty acids
%K diazoxide
%U http://www.frontiersin.org/Journal/10.3389/fendo.2014.00031/abstract