%0 Journal Article
%T Moonlighting functions of the NRZ (mammalian Dsl1) complex
%A Mitsuo Tagaya
%J Frontiers in Cell and Developmental Biology
%D 2014
%I Frontiers Media
%R 10.3389/fcell.2014.00025
%X The yeast Dsl1 complex, which comprises Dsl1, Tip20, and Sec39/Dsl3, has been shown to participate, as a vesicle-tethering complex, in retrograde trafficking from the Golgi apparatus to the endoplasmic reticulum. Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay. In this review, we summarize the current knowledge of the metazoan NRZ complex and discuss the ¡°moonlighting¡± functions and intercorrelation of their subunits.
%K autophagy
%K CATCHR tether complex
%K cell cycle
%K endoplasmic reticulum
%K mRNA decay
%K NAG
%K RINT1
%K ZW10
%U http://www.frontiersin.org/Journal/10.3389/fcell.2014.00025/abstract