%0 Journal Article
%T HMGA proteins as modulators of chromatin structure during transcriptional activation
%A Nihan Ozturk
%A Indrabahadur Singh
%A Aditi Mehta
%A Thomas Braun
%A Guillermo Barreto
%J Frontiers in Cell and Developmental Biology
%D 2014
%I Frontiers Media
%R 10.3389/fcell.2014.00005
%X High mobility group (HMG) proteins are the most abundant non-histone chromatin associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of chromatin locally and globally. Accessibility to DNA within chromatin is a central factor that affects DNA-dependent nuclear processes, such as transcription, replication, recombination, and repair. HMG proteins associate with different multi-protein complexes to regulate these processes by mediating accessibility to DNA. HMG proteins can be subdivided into three families: HMGA, HMGB, and HMGN. In this review, we will focus on recent advances in understanding the function of HMGA family members, specifically their role in gene transcription regulation during development and cancer.
%K HMGA
%K chromatin structure
%K transcription
%K development and cancer
%U http://www.frontiersin.org/Journal/10.3389/fcell.2014.00005/abstract