%0 Journal Article
%T Bacterial Sigma Factors as Targets for Engineered or Synthetic Transcriptional Control
%A Lakshmi Tripathi
%A Yan Zhang
%A Zhanglin Lin
%J Frontiers in Bioengineering and Biotechnology
%D 2014
%I Frontiers Media
%R 10.3389/fbioe.2014.00033
%X Sigma (考) factors are the predominant constituents of transcription regulation in bacteria. 考 Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Recently, engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in 考 factor based engineering or synthetic design. The manipulation of 考 factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on 考 factors that can be used to tune the regulatory network of bacteria.
%K sigma factor
%K strain engineering
%K bacterial stress tolerance
%K extremophile
%K synthetic biology
%U http://www.frontiersin.org/Journal/10.3389/fbioe.2014.00033/abstract