%0 Journal Article
%T Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
%A Xiaoqin Run
%A Yang Zhao
%A Chun-ling Dai
%A Khalid Iqbal
%A Fei Liu
%A Cheng-Xin Gong
%J Frontiers in Aging Neuroscience
%D 2014
%I Frontiers Media
%R 10.3389/fnagi.2014.00100
%X Background: It is well documented that elderly individuals are at increased risk of cognitive decline after anesthesia. General anesthesia is believed to be a risk factor for Alzheimer¡¯s disease (AD). Recent studies suggest that anesthesia may increase the risk for cognitive decline and AD through promoting abnormal hyperphosphorylation of tau, which is crucial to neurodegeneration seen in AD.
%K intranasal insulin
%K anesthesia
%K hyperphosphorylation of tau
%K brain insulin signaling
%K protein phosphatase 2A
%K tau protein kinases
%K Alzheimer¡¯s disease
%K propofol
%U http://www.frontiersin.org/Journal/10.3389/fnagi.2014.00100/abstract