%0 Journal Article %T Oral Tranexamic Acid in Hip and Knee Arthroplasty: A Prospective Cohort Study %A Stephen McGrath %A Piers Yates %A Gareth Prosser %J Open Journal of Orthopedics %P 215-220 %@ 2164-3016 %D 2014 %I Scientific Research Publishing %R 10.4236/ojo.2014.48035 %X Intravenous Tranexamic acid has been shown to decrease blood transfusion requirements in sur- gery. Little evidence exists regarding the much cheaper oral form. The objective of this cohort study was to evaluate whether oral tranexamic acid administration in patients undergoing elec- tive hip and knee replacement surgery resulted in decreased transfusion requirements. Methods: We assessed the transfusion requirements of 332 patients following unilateral total hip or knee arthroplasty, with the first 140 receiving no tranexamic acid and the next 192 given 1 g oral tranexamic acid one hour prior to and a further 1 g 4 hours post joint arthroplasty. Haemoglobin before and after surgery, the number of units transfused post-operatively and the incidence of deep vein thrombosis or pulmonary embolism were recorded. Results: In the first group, there were 22 instances of transfusion (15.7%) and a mean haemoglobin drop of 32.2 g/L, while the second (tranexamic acid) group had just 12 patients transfused (6.3%) and a mean haemoglobin drop of 24.6 g/L (both significantly less, p < 0.01). There was no significant difference in deep vein thrombosis or pulmonary embolism rates between groups. Conclusions: This is the first prospective study to analyze the outcome of oral tranexamic acid administration in hip and knee replacement. We conclude that oral tranexamic acid administration is a safe and effective means to decrease transfusion requirements in joint arthroplasty and is a much cheaper alternative to intravenous preparations of tranexamic acid. %K Tranexamic Acid %K Blood Loss %K Surgical %K Blood Conservation Strategy %K Total Hip Replacement %K Total Knee Replacement %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=48650