%0 Journal Article
%T Crystal Structure and Synthesis of 3<i>¦Â</i>-(<i>p</i>-Iodobenzoyloxy)-16<i>¦Á</i>,17<i>¦Á</i>-Epoxypregn-4-En-6,20-Dione
%A Alejandra Ch¨¢vez-Riveros
%A Marisa Cabeza
%A Eugene Bratoeff
%A Manuel Soriano-Garc¨ªa
%J Crystal Structure Theory and Applications
%P 39-47
%@ 2169-2505
%D 2014
%I Scientific Research Publishing
%R 10.4236/csta.2014.32005
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	<span lang=\"EN-US\"><span style=\"font-family:Verdana;\">3</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-(</span><i><span style=\"font-family:Verdana;\">p</span></i><span style=\"font-family:Verdana;\">-iodobenzoyloxy)-16</span><i><span style=\"font-family:Verdana;\">¦Á</span></i><span style=\"font-family:Verdana;\">,17</span><i><span style=\"font-family:Verdana;\">¦Á</span></i><span style=\"font-family:Verdana;\">-epoxypregn-4-en-6,20-dione
(7), C</span><sub><span style=\"font-family:Verdana;\">28</span></sub><span style=\"font-family:Verdana;\">H</span><sub><span style=\"font-family:Verdana;\">31</span></sub><span style=\"font-family:Verdana;\">O</span><sub><span style=\"font-family:Verdana;\">5</span></sub><span style=\"font-family:Verdana;\">I, was synthesized from the
commercially available 16-dehydropregnenolone acetate. X-ray diffraction
analysis of (1) demonstrated that it consisted of four rings, three
six-membered rings (A, B and C) and one five-membered ring (D). A, B, C and D
rings occur in an envelope, deformed chair, deformed chair, and the half chair conformations,
respectively. The absolute configurations of 7 for the chiral centers are 3S,
8S, 9S, 10R, 13S and 14S. The crystal of 3</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-(</span><i><span style=\"font-family:Verdana;\">p</span></i><span style=\"font-family:Verdana;\">-iodobenzoyloxy)-16</span><i><span style=\"font-family:Verdana;\">¦Á</span></i><span style=\"font-family:Verdana;\">,17</span><i><span style=\"font-family:Verdana;\">¦Á</span></i><span style=\"font-family:Verdana;\">-epoxypregn-4-en-6,20-dione
is in monoclinic crystal system with space group </span><i><span style=\"font-family:Verdana;\">P</span></i><span style=\"font-family:Verdana;\">2</span><sub><span style=\"font-family:Verdana;\">1</span></sub><span style=\"font-family:Verdana;\">, lattice constants: </span><i><span style=\"font-family:Verdana;\">a</span></i><span style=\"font-family:Verdana;\"> = 10.8567 (11), </span><i><span style=\"font-family:Verdana;\">b</span></i><span style=\"font-family:Verdana;\"> =
7.5479 (7), </span><i><span style=\"font-family:Verdana;\">c </span></i><span style=\"font-family:Verdana;\">= 16.0391 (16) <span style=\"font-family:Verdana, Helvetica, Arial;line-height:17.714284896850586px;white-space:normal;background-color:#FFFFFF;\">&amp;Aring;</span>, </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span
%K Progesterone Derivatives
%K Androgen Receptor
%K 5-Alpha-Reductase Inhibitors
%K Human Prostate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=47263