%0 Journal Article
%T Pulmonary Complications as a Cause of Death after Renal Transplantation
%A Ventsislava Pencheva
%A Daniela Petrova
%A Diyan Genov
%A Ognian Georgiev
%J Open Journal of Internal Medicine
%P 41-46
%@ 2162-5980
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojim.2014.42007
%X <span style=\"font-size:12px;font-family:Verdana;\">Objectives: To analyse the risk factors for
death as a result of pulmonary complications in kidney transplant patients.
Material and Methods: 267 patients after renal transplantation were prospec</span><span style=\"font-size:12px;font-family:Verdana;\">tively
studied. The kidney recipients were followed for the development of pulmonary
complica</span><span style=\"font-size:12px;font-family:Verdana;\">tions and their outcome for a period of 7 years.
Different noninvasive and invasive diagnostic tests were used in cases
suspected for lung disease. Results: Risk factors for death as a result of
pulmo</span><span style=\"font-size:12px;font-family:Verdana;\">nary complications are development of lung
diseases in the first six months after operation (P &lt; 0.05), and immunosuppressive
regimens that include mycophenolate mofetil (HR</span><span style=\"font-size:12px;font-family:Verdana;\">:</span><span style=\"font-size:12px;font-family:Verdana;\"> 3.216; 95%</span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">CI: 1.067 - 5.577; P</span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">=
0.011). The factors associated with lower rate of fatal outcome are positive se</span><span style=\"font-size:12px;font-family:Verdana;\">rology
test for Cytomegalovirus of the recipient before transplantation (P = 0.034)
and use of aza</span><span style=\"font-size:12px;font-family:Verdana;\">thioprine (HR</span><span style=\"font-size:12px;font-family:Verdana;\">:</span><span style=\"font-size:12px;font-family:Verdana;\"> 0.720; 95%</span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">CI: 0.526 - 0.986; P</span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">=
0.04). Conclusions: The risk factors may be used to identify patients at
increased risk for death due to the pulmonary complications. Strictly moni</span><span style=\"font-size:12px;font-family:Verdana;\">toring
of higher-risk patients can reduce the morbidity and mortality after renal
transplantation.</span>
%K Fatal Outcome
%K Recipient
%K Immunosuppression
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=46701