%0 Journal Article
%T Pharmacokinetics and Efficacy of Tilmicosin in the Treatment of <i>Pasteurella haemolytica</i> Bronchopneumonia in Calves
%A Ahmed M. Soliman
%A Amer Ramadan Ali Ayad
%J Pharmacology & Pharmacy
%P 514-523
%@ 2157-9431
%D 2014
%I Scientific Research Publishing
%R 10.4236/pp.2014.55061
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"line-height:1.5;font-family:Verdana;\">Tilmicosin was administered intravenously and
subcutaneously at a dose rate of 10 mg/kg bwt to determine its concentration in
blood and bronchial secretion as well as its kinetic behavior in healthy and </span><i><span style=\"line-height:1.5;font-family:Verdana;\">Pasteurella
haemolytica</span></i><span style=\"line-height:1.5;font-family:Verdana;\"> type A1-infected calves. Sever acute bronchopneumonia was
induced in 10 calves by inoculating them intra-tracheally with </span><i><span style=\"line-height:1.5;font-family:Verdana;\">P.
haemolytica</span></i><span style=\"line-height:1.5;font-family:Verdana;\"> type A1. The calves were treated with tilmicosin; 5 of these
received the drug intravenously and the other 5 were injected subcutaneously. After
a slow intravenous injection, the serum concentration-time curve indicated a
two compartment open model with a mean elimination half-lives (t</span><sub><span style=\"line-height:1.5;font-family:Verdana;\">1/2</span></sub></span><i><sub><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">b</span></sub></i><span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"line-height:1.5;font-family:Verdana;\">s) of 22.09 and 22.14 hours before and after infection, respectively. The
mean residence time (MRT) corrected for a bolus injection was 2.25 and 2.20
hours and the mean MRT</span><sub><span style=\"line-height:1.5;font-family:Verdana;\">inf</span></sub><span style=\"line-height:1.5;font-family:Verdana;\"> was 25.27 and 25.46 hours in healthy and </span><i><span style=\"line-height:1.5;font-family:Verdana;\">P.
haemolytica</span></i><span style=\"line-height:1.5;font-family:Verdana;\">-infected calves, respectively. </span></span><span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"line-height:1.5;font-family:Verdana;\">After subcutaneous injection, the drug was
eliminated more slowly (before and after infection) from serum and bronchial
secretions, with t</span><sub><span style=\"line-height:1.5;font-family:Verdana;\">1/2</span></sub></span><i><sub><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">b</span></sub></i><span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"line-height:1.5;font-family:Verdana;\">s of (24.60 and 25.85 hours) and (33.74 and 31.78
hours), respectively. The apparent volume of distribution (V</span><sub><span
%K Tilmicosin
%K Disposition Kinetics
%K Calves
%K Healthy
%K Diseased
%K Bronchial Secretion
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=46162