%0 Journal Article
%T The Relation between Canine Hip Dysplasia, Genetic Diversity and Inbreeding by Breed
%A Frank H. Comhaire
%J Open Journal of Veterinary Medicine
%P 67-71
%@ 2165-3364
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojvm.2014.45008
%X <span style=\"font-family:'Verdana','sans-serif';font-size:10pt;\">Objectives: To assess the relation between the prevalence of canine hip dysplasia, inbreeding and genetic diversity by breed. Methods: Retrospective pedigree analysis of 9 breeds based on a reference population of 41,728 individuals, and hip dysplasia assessment in 1745 dogs. Results: Hip dysplasia was less common among breeds with higher coefficient of inbreeding, lower genetic diversity, and highest contribution of one single ancestor to the population. Inbreeding not exceeding 3.25% should be considered safe since it will maintain a sufficiently high genetic diversity within the breed. Clinical Significance: Together with published data on single breeds, the present findings question the general assumption that line-breeding or in-breeding has an adverse effect on the prevalence of hip dysplasia. Hip assessment is indicated in all breeds, but better methods are needed for selecting dogs suitable for reproduction.</span>
%K Genetic Diversity
%K Effective Population Size
%K Inbreeding
%K Hip Dysplasia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=45804