%0 Journal Article
%T Analysis of Chicken T Cell-Mediated  Responses on Thymus after Immune Stress
%A Zhenhu Jia
%A Yufang Cao
%A Yaju Xue
%A Fangxiang Li
%A Min Liu
%A Cai Zhang
%A Yufei Yang
%A Jiangyan Duan
%J Journal of Immune Based Therapies, Vaccines and Antimicrobials
%P 22-28
%@ 2168-1554
%D 2014
%I Scientific Research Publishing
%R 10.4236/jibtva.2014.32003
%X <div align=\"justify\">
	In order to assess chicken T cell-mediated responses after immune stress, 200 two-week-old chickens were randomly divided into control group(C) and treatment groups (T<sub>1</sub> and T<sub>2</sub>). The live I-type of Newcastle disease vaccine (ND) was taken as the source of immunological stress. The chickens in group (T<sub>2</sub>) were injected with overdose of live I-type Newcastle disease vaccine. After vaccination, the dynamic changes of CD4<sup>+</sup>, CD8<sup>+</sup>T cells on thymus were detected by immunohisto-chemistry. The ultra-structure of T cells on thymus of the chickens in group (T<sub>2</sub>) was observed by electron microscopic. The result showed: (1) After immune stress, from day 1 to day 5, the number of the CD4<sup>+</sup>T cells significantly declined and reached the bottom at day 5, but the number of the CD8<sup>+</sup>T cells increased dramatically and peaked at day 5. (2) After immune stress, from day 1 to day 5, part of T cells of chicken thymus came with apoptotic and pathological changes of putrescence continually. These results underscore: the immune stress can cause transient immune adjustment. These changes for chickens were the self-protection mechanism of immune system to adapt to survival and avoid immune disorder.
</div>
%K T Cells
%K Chicken Thymus
%K Immunological Stress
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44721