%0 Journal Article
%T Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones
%A Norihisa Kusumoto
%A Nobuhiro Aburai
%A Tatsuya Ashitani
%A Koetsu Takahashi
%A Ken-ichi Kimura
%J Advances in Biological Chemistry
%P 109-115
%@ 2162-2191
%D 2014
%I Scientific Research Publishing
%R 10.4236/abc.2014.42015
%X Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from <i>Taxodium distichum</i> cones and their biological properties evaluated <i>in vitro</i> against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17¦Á-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.<br />
%K Abietane Diterpenoid
%K Conifer Cone
%K Antibacterial Activity
%K 17&lt
%K i&gt
%K ¦Á&lt
%K /i&gt
%K -Hydroxylase/C17
%K 20-Lyase
%K Prolyl Oligopeptidase
%K Cytotoxicity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44409