%0 Journal Article
%T Reaction Rate Models for the Thermal  Decomposition of Ibuprofen Crystals
%A Sundaram Ramukutty
%A Esakki Ramachandran
%J Journal of Crystallization Process and Technology
%P 71-78
%@ 2161-7686
%D 2014
%I Scientific Research Publishing
%R 10.4236/jcpt.2014.42010
%X <span style=\"font-size:10.0pt;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;font-size:12px;\">Kinetics of the decomposition of racemic ibuprofen crystals were studied
by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen
is thermally stable up to 152.6¡ãC and the initial loss of mass was due to
evaporation only. Activation energy, pre-exponential factor, activation entropy
and Gibbs free energy for the decomposition of ibuprofen were determined using
the integral method of Coats-Redfern (CR). Geometrical contraction models were
found to be the best fits. The Arrheinus equation for the thermal decomposition
of ibuprofen is k = (1.1 ¡Á 10</span><sup><span style=\"font-family:Verdana;font-size:12px;\">7</span></sup><span style=\"font-family:Verdana;font-size:12px;\">) e</span><sup><span style=\"font-family:Verdana;font-size:12px;\">¨C79125/RT</span></sup><span style=\"font-family:Verdana;font-size:12px;\"> sec</span><sup><span style=\"font-family:Verdana;font-size:12px;\">¨C1</span></sup><span style=\"font-family:Verdana;font-size:12px;\">.</span></span>
%K Ibuprofen
%K Model Fitting
%K Kinetics
%K Decomposition
%K Coats-Redfern Method
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44499