%0 Journal Article
%T Acute and Sub-Acute Toxicity of Ethanolic Leaf Extracts of <i>Rumex abyssinica</i> Jacq.  (Polygonaceae) and <i>Mentha spicata</i> L.  (Lamiaceae)
%A Maud Kamatenesi Mugisha
%A James Gakunga Ndukui
%A Agnes Namutembi
%A Paul Waako
%A Ann-Karl Borg Karlson
%A Patrick Vudriko
%J Pharmacology & Pharmacy
%P 309-318
%@ 2157-9431
%D 2014
%I Scientific Research Publishing
%R 10.4236/pp.2014.53038
%X <p style=\"text-align:justify;\">
	<i><span style=\"font-size:10pt;font-family:Verdana;\">Rumex</span></i><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> <i><span style=\"font-family:Verdana;\">abyssinica</span></i><span style=\"font-family:Verdana;\"> Jacq. (Polygonaceae</span><i><span style=\"font-family:Verdana;\">)</span></i><span style=\"font-family:Verdana;\"> is locally used
in management of allergies and female re</span></span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">productive
healthcare; whereas </span><i><span style=\"font-family:Verdana;\">Mentha</span></i> <i><span style=\"font-family:Verdana;\">spicata</span></i><span style=\"font-family:Verdana;\"> L. (Lamiaceae)</span><i> </i><span style=\"font-family:Verdana;\">is used to treat gastrointestinal and
respiratory distress, dandruff, halitosis and malaria in Uganda. Owing to the
paucity of data on their safety profiles, this study evaluated the acute and
sub-acute toxicities of 70% ethanolic leaf extracts of both plants in mice and
Wistar albino rats. The oral acute toxicity of both plants was evaluated in
Swiss mice of 7</span></span><span style=\"font-size:10pt;font-family:Verdana;\">-</span><span style=\"font-size:10pt;font-family:Verdana;\">8
weeks old (16</span><span style=\"font-size:10pt;font-family:Verdana;\">-</span><span style=\"font-size:10pt;font-family:Verdana;\">22</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">g) body weight and
LD</span><sub><span style=\"font-family:Verdana;\">50 </span></sub><span style=\"font-family:Verdana;\">determined. Sub-acute toxicity was evaluated in Wistar albino
rats (6 per group) at dose rates of 500, 1000 and 1500 mg/kg for 28 days. The
LD</span><sub><span style=\"font-family:Verdana;\">50</span></sub><span style=\"font-family:Verdana;\"> of </span><i><span style=\"font-family:Verdana;\">R. abyssinica </span></i><span style=\"font-family:Verdana;\">and </span><i><span style=\"font-family:Verdana;\">M. spicata </span></i><span style=\"font-family:Verdana;\">in mice </span></span><span style=\"font-size:10pt;font-family:Verdana;\">was</span><span style=\"font-size:10pt;font-family:Verdana;\"> 7727 mg/kg and 13,606 mg/kg body weight, respectively. General signs of toxicity due to large doses of both plants extract
included hyperurination, abdominal muscle twitches and convulsions. In the
sub-acute toxicity test, rats treated with both extracts did not exhibit
any clinical signs
%K Histopathology
%K &lt
%K i&gt
%K Mentha spicata
%K Rumex abyssinica&lt
%K /i&gt
%K Toxicity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44242