%0 Journal Article
%T Urinary Neutrophil Gelatinase Associated Lipocalin as a Marker of Tubular Damage in Type 2 Diabetic Patients with and without Albuminuria
%A Abeer A. Al-Refai
%A Safaa I. Tayel
%A Ahmed Ragheb
%A Ashraf G. Dala
%A Ahmed Zahran
%J Open Journal of Nephrology
%P 37-46
%@ 2164-2869
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojneph.2014.41006
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10pt;font-family:Verdana;\">Background: Neut</span><span style=\"font-size:10pt;font-family:Verdana;\">t</span><span style=\"font-size:10pt;font-family:Verdana;\">rophil gelatinase associated lipocalin (NGAL) was shown to be a good
marker for predicting acute kidney injury (AKI). Some recent reports
demonstrated that NGAL may be an early biomarker for kidney affection </span><span style=\"font-size:10pt;font-family:Verdana;\">i</span><span style=\"font-size:10pt;font-family:Verdana;\">n diabetic patients. The aim of this work is
to investigate urinary NGAL (UNGAL) in type 2 diabetic patients with and
without albuminuria. Methods: This study included 46 type 2 diabetic patients
and 15 healthy age and sex matched individual</span><span style=\"font-size:10pt;font-family:Verdana;\">s</span><span style=\"font-size:10pt;font-family:Verdana;\"> as </span><span style=\"font-size:10pt;font-family:Verdana;\">the </span><span style=\"font-size:10pt;font-family:Verdana;\">control group. Diabetic patients were divided into three groups according
to urinary albumin excretion (UAE), normoalbuminuria, microalbuminuria and
macroalbuminuria. UNGAL was mea</span><span style=\"font-size:10pt;font-family:Verdana;\">sured in all populations and corrected to urinary creatinine to account
for day to day variation in urine volume and transformed log. Comparison
between 4 groups (control, normoalbuminuria, microalbuminuria and
macroalbuminuria) was done. Results: Log UNGAL/Creatinine ratio show</span><span style=\"font-size:10pt;font-family:Verdana;\">ed significant difference when compar</span><span style=\"font-size:10pt;font-family:Verdana;\">ing</span><span style=\"font-size:10pt;font-family:Verdana;\"> control group (0.70 </span><span style=\"font-size:10pt;font-family:Verdana;\">¡À</span><span style=\"font-size:10pt;font-family:Verdana;\"> 0.58) versus normoalbuminuria (1.71 </span><span style=\"font-size:10pt;font-family:Verdana;\">¡À</span><span style=\"font-size:10pt;font-family:Verdana;\"> 1.06), microalbuminuria (1.57 </span><span style=\"font-size:10pt;font-family:Verdana;\">¡À</span><span style=\"font-size:10pt;font-family:Verdana;\"> 0.72) and macroalbuminuria (1.92 </span><span style=\"font-size:10pt;font-family:Verdana;\">¡À</span><span style=\"font-size:10pt;font-family:Verdana;\"> 0.63)</span><span style=\"font-size:10pt;font-family:Verdana;\">,</span><span style=\"font-size:10pt;font-family:Verdana;\"> however</span><span style=\"font-size:10pt;font-family:Verdana;\">,</span><span
%K Neutrophil Gelatinase Associated Lipocalin (NGAL)
%K Diabetic Nephropathy
%K Albuminuria
%K Tubular Markers
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44090